Tirzepatide, the newest weight loss craze! It is an analogue of gastric inhibitory polypeptide (GIP), a human hormone that stimulates the release of insulin from the pancreas. It is also a linear polypeptide of 39 amino acids that has been chemically modified by lipidation to improve stability of your metabolism. It's been shown in clinical studies that patients lost up to 20.9% of their body weight when used adjunctively with exercise and a healthy high protein diet.
Tirzepatide is a prescription medicine used for weight loss (Zepbound brand) and type 2 diabetes (Mounjaro brand) in adults. Tirzepatide works for weight loss by decreasing appetite and slowing the movement of food from the stomach into the small intestine, which may make you feel full more quickly and for a longer period of time. In type 2 diabetes, tirzepatide decreases blood sugar levels by increasing insulin production and lowering the amount of sugar the liver makes. Tirzepatide is given as an injection under the skin once a week. Tirzepatide is a GIP and GLP-1 receptor agonist.
How does tirzepatide work?
Tirzepatide is a GIP and GLP-1 receptor agonist, so it works (mechanism of action) by activating both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) hormone receptors. GLP-1 helps control appetite and calorie intake, and GIP is thought to contribute to regulating food intake as well.
How much weight loss can you expect on Tirzepatide?
Patients on tirzepatide 5mg weekly lost 16.1 kg (35.5 lb) on average after 72 weeks. For tirzepatide 10mg weekly dose, the average weight loss was 22.2 kg (48.9 lb), and for tirzepatide 15mg weekly dose average weight loss was 23.6 kg (52.0 lb) over 72 weeks. Patients who used a placebo lost 2.4 kg (5.3 lb) over the 72 weeks.
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